Document 0449
 DOCN  M9480449
 TI    Tuberculosis and HIV infection in children in Abidjan, Cote d'Ivoire.
 DT    9410
 AU    Sassan-Morokro M; De Cock KM; Ackah A; Vetter KM; Doorly R; Brattegaard
       K; Coulibaly D; Coulibaly IM; Gayle H; Projet RETRO-CI, Abidjan, Cote
       d'Ivoire.
 SO    Trans R Soc Trop Med Hyg. 1994 Mar-Apr;88(2):178-81. Unique Identifier :
       AIDSLINE MED/94310627
 AB    Of 5180 consecutive outpatients diagnosed with tuberculosis in Abidjan,
       Cote d'Ivoire (West Africa), between July 1989 and December 1990, 289
       (6%) were children aged less than 15 years. The overall prevalence of
       human immunodeficiency virus (HIV) 1 and/or HIV-2 infection in children
       with tuberculosis was 11.8% (HIV-1, 10.0%; HIV-2, 0.7%; reactivity to
       both viruses, 1%). The highest overall age-specific prevalence was in
       children aged 1-4 years (23.4%), significantly higher than the rate in
       attenders at a well child clinic (0.5%) (odds ratio 58.2). Of children
       with tuberculosis, 26% had sputum smear-positive disease (HIV
       seroprevalence 2.7%), 20% extrapulmonary disease (HIV seroprevalence
       5.2%), and 54% were categorized as having 'clinical tuberculosis' (HIV
       seroprevalence 18.6%) based on clinical signs and chest X-ray
       abnormalities with negative sputum smears. Clinical tuberculosis was
       most frequent in seropositive children, irrespective of age, and in
       younger seronegative children. Extrapulmonary tuberculosis was equally
       distributed across age groups, and pulmonary tuberculosis was
       concentrated in older, seronegative children. HIV-positivity was
       significantly associated with other features related to the acquired
       immune deficiency syndrome such as wasting, chronic diarrhoea, oral
       candidiasis, and negative tuberculin skin tests. Tuberculosis seems to
       be associated with HIV infection in children in sub-Saharan Africa, but
       better diagnostic techniques for paediatric tuberculosis are urgently
       needed.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*EPIDEMIOLOGY
       Adolescence  Age Distribution  Child  Child, Preschool  Cote
       d'Ivoire/EPIDEMIOLOGY  Human  HIV Seroprevalence  Infant  Prevalence
       Support, Non-U.S. Gov't  Tuberculosis/COMPLICATIONS/*EPIDEMIOLOGY
       Tuberculosis, Pulmonary/COMPLICATIONS/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).